1,3(2H,4H)-Isoquinolinedione, 4-[(1-methyl-1H-pyrrol-2-yl)methylene]-
4-[(1-Methyl-1H-Pyrrol-2-yl)Methylene]-1,3(2H,4H)-Isoquinolinedione
CAS: 1104546-89-5
Molecular Formula: C15H12N2O2
1,3(2H,4H)-Isoquinolinedione, 4-[(1-methyl-1H-pyrrol-2-yl)methylene]- - Names and Identifiers
1,3(2H,4H)-Isoquinolinedione, 4-[(1-methyl-1H-pyrrol-2-yl)methylene]- - Physico-chemical Properties
| Molecular Formula | C15H12N2O2 |
| Molar Mass | 252.27 |
| Density | 1.27±0.1 g/cm3(Predicted) |
| Boling Point | 492.5±45.0 °C(Predicted) |
| Solubility | DMSO : 125 mg/mL (495.50 mM; Need ultrasonic) |
| Appearance | powder |
| Color | yellow |
| pKa | 9.30±0.20(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | In kinetic experiments with human PARP-1, BYK204165 exhibits potent and competitive inhibition of enzyme activity, yielding a pK i value of 7.05. BYK204165 exhibits low potency of PARP inhibition in C4I cells (pIC 50 of 5.75). |
| In vivo study | BYK204165 is not investigated in vivo because of its short half-time (t 1/2 ) of 23 min measured at rat microsomes in vitro. |
1,3(2H,4H)-Isoquinolinedione, 4-[(1-methyl-1H-pyrrol-2-yl)methylene]- - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 43 - May cause sensitization by skin contact |
| Safety Description | 36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
1,3(2H,4H)-Isoquinolinedione, 4-[(1-methyl-1H-pyrrol-2-yl)methylene]- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.964 ml | 19.82 ml | 39.64 ml |
| 5 mM | 0.793 ml | 3.964 ml | 7.928 ml |
| 10 mM | 0.396 ml | 1.982 ml | 3.964 ml |
| 5 mM | 0.079 ml | 0.396 ml | 0.793 ml |
Last Update：2024-01-02 23:10:35
1,3(2H,4H)-Isoquinolinedione, 4-[(1-methyl-1H-pyrrol-2-yl)methylene]- - Reference Information
| biological activity | BYK204165 is an effective selective inhibitor of poly(ADP-ribose) polymerase (PARP). The pIC50 and pKi values corresponding to human PARP-1 (hPARP-1) that BYK204165 can inhibit cell-free recombination are 7.35 and 7.05, respectively, and the pIC50 value for mouse PARP-2 (mPARP-2) is 5.38. |
| target | cell-free hPARP-1 7.35(pIC50) hPARP-1 7.05(pKi) mPARP-2 5.38(pIC50) |
| Target | Value |
| hPARP-1 (Cell-free assay) | 7.35(pIC50) 7.05(pKi) |
| mPARP-2 (Cell-free assay) | 5.38(pIC50) |
| in vitro study | in kinetic experiments with human PARP-1, BYK204165 exhibits potent and competitive inhibition of enzyme activity, yielding a pK I value of 7.05. BYK204165 exhibits low potency of PARP inhibition in C4I cells (pIC 50 of 5.75). |
| in vivo study | BYK204165 is not investigated in vivo because of its short half-time (t 1/2 ) of 23 min measured at rat microsomes in vitro. |
Last Update：2024-04-10 22:41:56
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Spot supply
Product Name: 4-[(1-Methyl-1H-Pyrrol-2-yl)Methylene]-1,3(2H,4H)-Isoquinolinedione Visit Supplier Webpage Request for quotationCAS: 1104546-89-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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